MLB Wild Card Betting Preview: Series Winners, Odds and Upsets

Ladies and gentlemen, we have officially arrived. Major League Baseball Wild Card Weekend begins tomorrow, as eight teams are set to begin their journey in becoming World Champions of baseball. Luckily for us in Philadelphia, the Phillies are making their first appearance since 2011 and god damnit do we expect an upset in St. Louis.
2022 MLB Postseason Bracket

MLB Wild Card Matchups
- Guardians (3) vs. Rays (6)
- Blue Jays (4) vs. Mariners (5)
- Cardinals (3) vs. Phillies (6)
- Mets (4) vs. Padres (5)
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Philadelphia Phillies vs. St. Louis Cardinals
The Philadelphia Phillies are back in the postseason facing the team that basically ended their dynasty back in 2011 in the St. Louis Cardinals.
The Phillies are currently slight underdogs to win the series at +106 but if you’re looking for any team to pull off an upset in the Wild Card round, it’s the Fightins.
The Philadelphia Phillies won the regular season series 4-3 against the St. Louis Cardinals.
St. Louis is just 6-8 over their last 14 games and have scored two runs or fewer nine times during that span. First, let’s look at how the Cardinals core performed over the past month.
Game 1 First Pitch at 2:07 EST on Friday. For the group of thousands traveling with Phans of Philly to Arizona for the Eagles-Cardinals game on Sunday, Phans has us set up at 11AM for the game in Old Town Scottsdale.
Buckle up. It’s going to be a long day.
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Tampa Bay Rays vs. Cleveland Guardians
The Cleveland Guardians are a -120 favorite over the Tampa Bay, but much like the Phillies, the Rays aren’t heavy underdogs in this series either. They currently sit at +102 on the books and honestly, I could see it shifting even more before the series starts.
Tampa Bay is the sixth seed in the AL, they’re still a scary team, especially with their past playoff experience over the last few years. Shane McClanahan will take the hill for the Rays in Game 1, and Shane Bieber will get the ball for the Guardians.
Game 1 kicks off at 12:07 EST on Friday
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Seattle Mariners vs. Toronto Blue Jays
The Seattle Mariners, just like the Phillies, snapped the longest playoff drought in the American League last week and are looking to play spoiler to a power-hitting Blue Jays lineup.
Seattle opens up as a pretty significant underdog at +148, as the Blue Jays are sitting at -174 at home, where some dude just tried to propose to his girlfriend with a Ring Pop.
Fake proposals aside, I like the Blue Jays in the Wild Card round.
Luis Castillo, who was acquired from the Reds at the trade deadline, will go in Game 1 for the Mariners, with slinging right-hander Alek Manoah will throw for Toronto.
Game 1 kicks off at 4:07 EST on Friday.
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San Diego Padres vs. New York Mets
The 100-win Mets weren’t supposed to be playing this weekend, but after getting manhandled by the Braves down the stretch, they find themselves facing off against Slam Diego in the MLB Wild Card Round.
Side Note: Do people still call the Padres “Slam Diego” after Tatis got caught juicing?
Pitching matchups are unknown for Game 1 as of right now, although I’d have to assume that San Diego would throw Yu Darvish and Joe Musgrove in the first two games. Max Scherzer will go in one of the first two games for New York, and if healthy, deGrom will almost certainly pitch Game 2.
Game 1 kicks off at 8:07 EST
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MLB Wild Card Parlay
- Cleveland Guardians -120
- Philadelphia Phillies +106
- San Diego Padres +164
- Toronto Blue Jays -174