Chiefs-Cardinals Betting Preview: Bet $20 on Arizona +6, get $550 FREE
Two of the best offenses in the NFL will take center stage this week when the Kansas City Chiefs head across the country to take on the Arizona Cardinals.
Kansas City Chiefs at Arizona Cardinals
Sunday, September 11 | 4:25 PM EST | State Farm Stadium | Glendale, AZ
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Chiefs-Cardinals Betting Odds Via BetMGM
| TEAM | SPREAD | MONEY | TOTAL |
| Chiefs | -6 (-115) | -250 | O 53.5 (-110) |
| Cardinals | +6 (-105) | +200 | U 53.5 (-110) |
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Although both Arizona and Kansas City are fresh off postseason appearances, both squads have something to prove in 2022.
In KC, Patrick Mahomes will be without explosive playmaker Tyreek Hill for the first time in his career, as the wideout was traded to Miami this offseason. The Chiefs went out and acquired a handful of pass catchers to try and fill the void, signing JuJu Smith-Schuster and Marquez Valdes-Scantling along with drafting Skyy Moore.
Arizona will look to avoid another second-half collapse this season. After starting 8-1 in 2021, the Cardinals finished at 11-6, going 3-5 down the stretch. Without All-Pro wideout DeAndre Hopkins in the lineup for the first six games of the season due to a PED violation, Kyler Murray and Co. will have their work cut out for them.
Key Matchup: Cardinals passing attack vs. new-look Chiefs secondary
Even though Murray won’t have his go-to receiver in this one, the Cardinals still have an assortment of offensive weapons to choose from.
Newly acquired Marquise Brown will assume to No. 1 receiver role in Hopkins’ absence and should add a legitimate deep threat to the Cardinals arsenal. Veterans Zach Ertz and AJ Green are both passed their prime, but they both will still present matchup problems for KC’s new-look secondary.
Now that Tyrann Mathieu is no longer patrolling the backend of KC’s defense, Justin Reid will start at safety after signing with the Chiefs this past offseason. The veteran safety had a rough 2021 outing, posting a Pro Football Focus grade of 50.9 for the year, which ranked him as the 86th-best safety in football.
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On the outside, the Chiefs defense will have to rely on rookie Trent McDuffie at cornerback. The rookie certainly has potential, but cornerback is naturally one of the hardest positions to transition to from the college game. He’ll have his work cut out for him facing this prolific Arizona passing attack.
If history is any indication, Arizona will come out on fire in Week 1. Kliff Kingsbury hasn’t lost an opening day game since becoming the Cardinals head coach back in 2020. His record in September and October is a combined 15-8-1 since 2020.
Kingsbury’s teams always come out of the gates red hot and I don’t expect that to change this time around. They may not get the W on Sunday, but they’ll keep it close and may have a chance to win in the end.
I like the +6 spread for Arizona this week, and with Murray and Mahomes under center for both squads, expect the O 53.5 point total to hit as well.
Key Trends for Sunday’s contest
Kansas City has a 9-3-1 all-time record facing Arizona.
Their last meeting came in 2018; KC won 26-14.
Arizona went 10-9 against the spread last season, Kansas City went 8-9.
The Chiefs hit the over in point total 60 percent of the time last season, Arizona hit it in 44 percent of their games.
This will be the first time Kyler Murray has faced an opponent from the AFC West.
Patrick Mahomes has a 13-2 all-time record against NFC opponents in his career.
The two losses came against NFC West team (Seahawks, Rams)
Picks: Arizona +6 (-105) | O 53.5 point total (-110)
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Mandatory Credit: Sam Greenwood | Getty Images
